Tuesday, September 1st 2020
Wednesday, September 2nd 2020
Thursday, September 3rd 2020
Friday, September 4th 2020
- Thursday, September 3rd 2020: Gala Dinner - To Be Advice
HHMI - Baylor College of Medicine- Huston
He is interested in (1) providing a better fundamental understanding of the biology that governs the proper function and maintenance of neurons in aging adults (2) developing tools that can be applied to most genes to control transcript and protein levels in adult neurons to assess which proteins are required for neuronal survival and proper function (3) creating genome wide libraries to manipulate most genes in vivo. My lab uses the fruit fly Drosophila melanogaster as a model system because most biological processes are evolutionarily conserved and studies in fruit flies provide many important clues about the aging process in animals and human diseases.
Crick Institute- London
He is interested in how the environment shapes our physiology and metabolism and how this impacts upon health and disease. His research focuses on identifying the protective mechanisms that allow developing and adult animals to cope with environmental challenges such as malnutrition and oxidative stress. This research also aims to shed light on the complex interactions between environmental factors and the genes influencing metabolic and age-related diseases.
University of Edinburgh
Her research is about modeling the sensorimotor capabilities of insects. This ranges from simple reflexive behaviors such as the phonotaxis of crickets, to more complex capabilities such as multimodal integration, navigation and learning. We carry out behavioral experiments on insects, but principally work on computational models of the underlying neural mechanisms, which are often embedded on robot hardware.
Instituto Leloir- Buenos Aires
The circadian clock sets the timing for gene expression, cell metabolism, physiology and behavior to the most critical moments in the day, thus contributing to the organism’s adaptation to a changing environment. Although the molecular mechanisms underlying the biological clock at a cell-autonomous level have been explored at length, most organisms from invertebrates to mammals rely on the coordinated action of different oscillators that are localized in neuronal clusters in the adult brain, and even in different tissues. How the different oscillators in the brain are coupled and synchronize peripheral oscillators to render a coherent output remains largely unexplored in both invertebrate and mammals. One of the long-term goals of our laboratory is to unravel the molecular and cellular basis underlying the control of rhythmic physiology and behavior, and how these properties change throughout life under normal or pathological circumstances, such as aging or neurodegeneration; we employ Drosophila as the model system.
Vollum Institute- Portland
Neurons are not alone in the nervous system. Glial cells constitute the majority of the cells in the human brain. Despite their abundance, we know surprisingly little about how glia develop or function in the mature nervous system. Understanding glial cell biology and neuron-glia interactions has become an important line of investigation in contemporary neuroscience. Exciting recent work from the field has demonstrated central roles for this enigmatic cell type in neural circuit assembly, function, and plasticity. Moreover, glial cells appear to be primary responders to neuronal injury and neurodegenerative disease, but whether they are directly affected by disease, are responding to disease, or are in fact driving neuronal loss during disease remains unclear. Defining the precise roles that glia play will be a crucial step if we wish to understand how the nervous system is assembled, functions to drive animal behavior, and is maintained in a healthy state for the life of an animal.
TUM School of Life Sciences- Munich
Perceptions and decisions depend on sensory impressions, but also on past experiences and the present internal state of an animal. Behavior is therefore very adaptive and flexible. For instance, a hungry animal perceives the smell and taste of food as much more positive than a fed animal. At the same time, it is willing to take a high risk and invest time and energy in order to find food. Which signals and neural networks allow the communication between brain and body? And how do they modulate behavior and decision-making in the best interest of the organism?
We aim at answering these questions at three levels: (1) behavior, (2) neural networks, and (3) genes. To this end, we are using genetic models such as Drosophila melanogaster in combination with modern techniques including high resolution behavioral analysis, optogenetics, and in vivo multiphoton microscopy. In particular, we focus on how the brain translates chemosensory information, i.e. odors and tastes, into state- and experience-dependent perceptions and ultimately into behavior.
University of Dundee
We are interested in understanding the generation of cell fates. The division of stem cells can be linked to cell fate choices and we adress the question how stem cells manage to produce two different cell types through a single division. In the focus of our studies are neuroblasts, stem cells from the developing central nervous system of Drosophila.
We use cell and developmental biology approaches to try to improve our understanding of the molecular mechanisms that stem cells use to renew themselves while simultaneously generating daughter cells that will differentiate. This process is called asymmetric cell division and relies on the establishment of cell polarity, the orientation of the mitotic spindle and the differential segregation of cellular content to the daughter cells. In particular we focus on the dynamic changes of cell polarity through the cell cycle and its relation to cell fate decisions.